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目的:在血清学水平上探讨C反应蛋白(CRP)、基质金属蛋白酶2(MMP2)与冠状动脉粥样硬化斑块破裂的关系,评价CRP、MMP2水平作为粥样硬化斑块破裂的血清学指标的意义。方法:分别利用酶联免疫吸附法及散射比浊法对40例急性冠状动脉综合征(ACS)组、40例稳定型心绞痛(SAP)组、40例非冠心病者(正常对照组)外周血血清CRP、MMP2水平进行测定。结果:ACS组、SAP组血清CRP、MMP2水平明显高于正常对照组,差异具有统计学意义(P<0.01),ACS组血清CRP、MMP2水平明显高于SAP组,差异具有统计学意义(P<0.01);经相关性检验血清CRP和MMP2水平呈明显正相关(P<0.01)。结论:血清CRP、MMP2水平可反映斑块稳定性,可作为检测斑块破裂的血清学指标。
OBJECTIVE: To investigate the relationship between C-reactive protein (CRP), matrix metalloproteinase 2 (MMP2) and coronary atherosclerosis plaque rupture at the serological level and to evaluate the levels of CRP and MMP2 as serological markers of atherosclerotic plaque rupture Meaning. Methods: Peripheral blood was collected from 40 patients with acute coronary syndrome (ACS), 40 patients with stable angina (SAP), 40 patients with non-coronary heart disease (normal control group) by enzyme-linked immunosorbent assay (ELISA) Serum CRP, MMP2 levels were measured. Results: Serum levels of CRP and MMP2 in ACS group and SAP group were significantly higher than those in normal control group (P <0.01). Serum levels of CRP and MMP2 in ACS group were significantly higher than those in SAP group (P <0.01). Correlation test showed that serum CRP and MMP2 levels were positively correlated (P <0.01). Conclusion: Serum levels of CRP and MMP2 can reflect the stability of plaque, which can be used as a serological marker to detect plaque rupture.