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目的 :观察胎盘免疫调节因子 (PIF)对病人细胞免疫功能及体液免疫功能的影响。方法 :利用 PIF治疗妇科恶性肿瘤 6 3例 ,并设对照组 6 3例。治疗组病人每天肌注 PIF4ml,30 d为一疗程 ,对照组不注射 PIF。两组病人治疗前及治疗 30d后抽血检测 T淋巴细胞亚群 (CD3、 CD4、 CD8)、 NK细胞活性、淋巴细胞转化率 (L T)及免疫球蛋白 (Ig A、 Ig G、 Ig M)。结果 :经 PIF治疗后 ,治疗组病人 CD3、CD4、CD4/CD8、L T及 NK细胞活性均明显增高 ,Ig A、Ig G、Ig M也明显增高 ,而对照组的上述指标均有所降低。结论 :PIF能提高妇科恶性肿瘤病人的细胞免疫功能及体液免疫功能。
Objective: To observe the effect of placental immunomodulatory factor (PIF) on cellular immune function and humoral immune function. Methods: Sixty-three cases of gynecologic malignancies were treated with PIF, and 63 cases were assigned as control group. The patients in the treatment group were intramuscularly injected with PIF 4 ml daily for 30 days, while the control group did not receive PIF. T lymphocyte subsets (CD3, CD4, CD8), NK cell activity, lymphocyte transformation rate (LT) and immunoglobulin (Ig A, Ig G, Ig M) were measured before and 30 days after treatment in both groups. . Results: After treatment with PIF, the activity of CD3, CD4, CD4 / CD8, L T and NK cells in the treatment group were significantly increased, Ig A, Ig G and Ig M were also significantly increased, while the control group of the above indicators were reduced. Conclusion: PIF can improve cellular immune function and humoral immune function in patients with gynecological malignant tumors.