妊娠可看作是一种成功的同种半异体移植。在这个过程中,母体免疫系统存在特殊的免疫调节,使胎儿不被排斥。妊娠早期人类白细胞抗原G,E,C(HLA-G,HLA-E,HLA-C)在绒毛外细胞滋养层表达,作用于免疫细胞,调节母体免疫。妊娠晚期胎盘产生细胞因子调节细胞免疫和体液免疫平衡,维持正常妊娠。如这种调节机制异常,会导致病理性妊娠,如子痫前期。对正常妊娠及子痫前期的免疫调节进行综述。 Pregnancy can be seen as a successful allogeneic allograft. In the process, the mother’s immune system has a special immunomodulatory effect that keeps the fetus from being rejected. Early pregnancy, human leukocyte antigen G, E, C (HLA-G, HLA-E, HLA-C) in the villi outside the trophoblast expression, the role of immune cells to regulate maternal immunity. Placental production of cytokines in late pregnancy regulate cellular and humoral immune balance and maintain normal pregnancy. Such as the abnormal regulation of the mechanism will lead to pathological pregnancy, such as preeclampsia. The immune regulation of normal pregnancy and preeclampsia are reviewed.