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Background:A comprehensive metabolism network of engineered E.coli is very important in systems biology and metabolomics studies.Many tools focus on two-dimensional space to display pathways in metabolic network.However,the usage of three-dimensional visualization may help to understand better the intricate topology of metabolic and regulatory networks.Methods:We manually curated large amount of experimental data (including pathways,reactions and metabolites) from literature related with different types of engineered E.coil and then utilized a novel technology of three dimensional visualization to develop a comprehensive metabolic network named SynBioEcoli.Results:SynBioEoli contains 740 biosynthetic pathways,3,889 metabolic reactions,2,255 chemical compounds manually curated from about 11,000 metabolism publications related with different types of engineered E.coli.Furthermore,SynBioEcoli integrates with various informatics techniques.Conclusions:SynBioEcoli could be regarded as a comprehensive knowledgebase of engineered E.coli and represents the next generation cellular metabolism network visualization technology.It could be accessed via web browsers (such as Google Chrome) supporting WebGL,at http://www.rxnfinder.org/synbioecoli/.