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全世界慢性乙型肝炎病毒 (ＨＢＶ)感染者超过 3 5亿人 ,而我国超过 1 2亿人 ,其中 10 %将死于ＨＢＶ持续感染后引起的肝硬化和肝癌。ＨＢＶ持续复制和宿主免疫功能异常是引起ＨＢＶ感染后慢性化以及慢性乙型肝炎 (ＣＨＢ)急性发作的主要因素 ,其中ＣＨＢ急性发作者极易进展至肝
Over 350 million people are infected with chronic hepatitis B virus (HBV) in the world, while more than 120 million people in our country die of it. Of these, 10% will die of cirrhosis and liver cancer caused by persistent HBV infection. Persistent HBV replication and host immune dysfunction are the major causes of chronic HBV infection and acute exacerbation of chronic hepatitis B (CHB), and acute exacerbation of CHB can easily progress to the liver