自从1986年Furchgott和Lgnarro发现内源性血管舒张因子的本质是一氧化氮(NO)以来,国内外有关NO的研究迅猛发展,成为生化领域的一大研究热点,至今方兴未艾。NO参与多种生理过程的调节,在多种疾病的发病机理中有重要作用。将NO与嗅觉联系起来,必能促进嗅觉生理的研究,对嗅觉障碍机理的阐明也会有一定的帮助。本文探讨NO在嗅觉生理和病理生理方面的作用。 Since 1986, when Furchgott and Lgnarro discovered that the essence of endogenous vasodilator is nitric oxide (NO), the research on NO at home and abroad has been developing rapidly and has become a hot research topic in biochemistry. NO is involved in the regulation of a variety of physiological processes and plays an important role in the pathogenesis of various diseases. Associating NO with the sense of smell will surely promote the study of olfactory physiology and will help to clarify the mechanism of olfactory disorders. This article explores the role of NO in olfactory physiology and pathophysiology.