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目的探讨介入热灌注化疗中晚期肝癌患者免疫功能的影响。方法采用流式细胞仪检测60例原发性肝癌患者介入热灌注热化疗前后T细胞亚群细胞的变化,并与40例常规介入化疗栓塞组进行比较。结果两组CD3+、CD4+、CD4+/CD8+升高,CD8+下降(P<0.05);热疗组CD3+、CD4+、CD4+/CD8+明显高于非热疗组,差异有统计学意义(P<0.05)。结论介入灌注化疗可以提高中晚期肝癌患者的细胞免疫功能。
Objective To investigate the effect of interventional chemotherapy on the immune function of patients with advanced liver cancer. Methods Flow cytometry was used to detect the changes of T lymphocyte subsets in 60 patients with primary liver cancer before and after thermal perfusion chemotherapy and compared with 40 patients with conventional chemoembolization. Results The levels of CD3 +, CD4 +, CD4 + / CD8 + and CD8 + in the two groups were significantly decreased (P <0.05). The levels of CD3 +, CD4 + and CD4 + / CD8 + in hyperthermia group were significantly higher than those in non-hyperthermia group. Conclusion Interventional infusion chemotherapy can improve cellular immune function in patients with advanced liver cancer.