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目的 :观察肉瘤样肾细胞癌 (SRCC)的临床病理特征。方法 :对 5例SRCC的临床病理特征、免疫表型及影响预后的因素进行评价。结果 :组织学检查分为双相性SRCC 4例 ,由癌和肉瘤样成分组成 ;单相性 1例 ,由差分化的肉瘤样梭形细胞、单核细胞与破骨细胞样多核巨细胞组成。 5例肉瘤样成分角蛋白阳性 ,4例波形蛋白阳性。结论 :SRCC为高度恶性的上皮性肿瘤 ,形态特征为癌细胞具有双重分化 ,临床分期是影响患者预后的重要因素
Objective: To observe the clinicopathological features of sarcomatoid renal cell carcinoma (SRCC). Methods: The clinicopathological features, immunophenotypes and prognostic factors of 5 cases of SRCC were evaluated. Results: Histological examination was divided into 4 cases of biphasic SRCC, which consisted of carcinoma and sarcomatoid components; 1 case of monophasicity, which consisted of differentiated sarcoid-like spindle cells, mononuclear cells and osteoclast-like multinucleated giant cells. 5 cases of sarcomatoid keratin-positive component, 4 cases of vimentin positive. Conclusion: SRCC is a highly malignant epithelial tumor characterized by double differentiation of cancer cells. Clinical staging is an important factor affecting the prognosis of patients