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目的:探讨不同水平细胞角蛋白片段抗原21-1(CYFRA21-1)、糖类抗原125(CA125)、癌胚抗原(CEA)和神经元特异性烯醇化酶(NSE)在肺癌诊断中的价值。方法:采用电化学发光免疫法检测54例肺癌患者、60例健康体检者和60例肺部良性疾病患者的CYFRA21-1、CAl25、CEA和NSE水平,对不同组别和不同肺癌分型患者之间的肿瘤标志物水平进行统计学分析。结果:肺癌组CYFRA21-1、CAl25、CEA、NSE水平均高于良性疾病组和健康组(P<0.05);小细胞癌患者NSE水平显著高于鳞癌、腺癌患者(P<0.05);肺癌组各肿瘤标志物联合检测阳性例数显著高于各肿瘤标志物单个检测阳性例数(P<0.05);联合检测敏感性、准确性均高于肿瘤标志物单项检测(P<0.05)。结论:CYFRA21-1、CAl25、CEA和NSE可作为肺癌患者早期诊断的辅助指标,四者联合检测可提高诊断的准确性和敏感性。
Objective: To investigate the value of different levels of CYFRA21-1, CA125, CEA and NSE in the diagnosis of lung cancer . Methods: The levels of CYFRA21-1, CA125, CEA and NSE in 54 patients with lung cancer, 60 healthy subjects and 60 patients with benign lung diseases were detected by electrochemiluminescence immunoassay. The levels of CYFRA21-1, CA125, CEA and NSE in different groups and different types of lung cancer Between the level of tumor markers for statistical analysis. Results: The levels of CYFRA21-1, CA125, CEA and NSE in lung cancer group were significantly higher than those in benign disease group and healthy group (P <0.05). The NSE level in patients with small cell carcinoma was significantly higher than that in squamous cell carcinoma and adenocarcinoma group (P <0.05). The positive number of all the tumor markers in lung cancer group was significantly higher than that of each tumor marker (P <0.05). The sensitivity and accuracy of combined detection were higher than those of single tumor marker (P <0.05). Conclusion: CYFRA21-1, CA125, CEA and NSE can be used as auxiliary indicators for the early diagnosis of lung cancer patients. The combination of the four tests can improve the diagnostic accuracy and sensitivity.