目的:评估成人变应性鼻炎(allergic rhinitis,AR)患者的症状和生活质量及两者的相关性,同时评估皮肤点刺试验结果与症状、生活质量的相关性。方法:用症状视觉模拟评分量表(visual analog scale,VAS)评价患者的症状严重程度,用鼻结膜炎相关生活质量问卷(Rhinoconjunctivitis Quality of Life Questionnaire,RQLQ)评价患者的生活质量,记录皮肤点刺试验结果,并进行统计学分析。结果:(1)VAS各项症状间比较有显著性差异(F=264.89,P<0.01),喷嚏是患者的首要症状(64.47±26.14)。(2)RQLQ 7方面间及各项目间比较均有显著性差异(F=29.15,P<0.01;F=34.65,P<0.01),生活质量最受影响的方面是鼻部症状(2.72±1.68),评分最高的项目是喷嚏(3.27±1.49)。(3)两量表有显著相关,其中,难以入睡、夜间醒来次数、睡眠质量不高与鼻塞VAS评分呈正相关(r=0.310,P=0.000;r=0.323,P=0.000;r=0.329,P=0.000),工作效率下降、注意力难以集中与难以入睡、夜间醒来次数、睡眠质量不高呈正相关,无耐心或烦躁与鼻塞、喷嚏VAS评分呈正相关(r=0.228,P=0.001;r=0.145,P=0.036),易怒与鼻塞VAS评分呈正相关(r=0.180,P=0.009),因症状而感到尴尬与喷嚏VAS评分呈正相关(r=0.150,P=0。030)。(4)皮肤点刺试验结果与两量表均无显著相关。结论:成人AR患者鼻部症状的严重程度与其生活质量显著相关,其中鼻塞、喷嚏可能是影响患者生活质量的主要原因;变应原级别与症状严重程度及生活质量无显著相关。 OBJECTIVE: To assess the symptoms and quality of life of adult patients with allergic rhinitis (AR) and the correlation between the two. Meanwhile, to evaluate the correlation between skin prick test results and symptoms and quality of life. Methods: The symptom severity of patients was assessed by visual analog scale (VAS). The quality of life was evaluated by Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) Test results, and statistical analysis. Results: (1) The symptoms of VAS were significantly different (F = 264.89, P <0.01). Sneeze was the most important symptom in patients (64.47 ± 26.14). (2) There was a significant difference between RQLQ 7 items and items (F = 29.15, P <0.01; F = 34.65, P <0.01). The most affected aspects of quality of life were nasal symptoms (2.72 ± 1.68 ), The highest rated item was sneeze (3.27 ± 1.49). (3) There was a significant correlation between the two scales, in which it was difficult to fall asleep, the number of waking at night and the quality of sleep were not significantly correlated with VAS score of nasal obstruction (r = 0.310, P = 0.000; r = 0.323, P = 0.000; , P = 0.000). There was a positive correlation between work efficiency and difficulty in falling asleep, difficulty in falling asleep during nighttime, number of wakefulness at night and poor sleep quality. No patient or irritability was positively correlated with VAS score of nasal obstruction and sneeze (r = 0.228, P = 0.001) ; r = 0.145, P = 0.036). There was a positive correlation between irritability and VAS score of nasal obstruction (r = 0.180, P = 0.009) . (4) skin prick test results were not significantly correlated with the two scales. CONCLUSIONS: The severity of nasal symptoms in adults with AR is significantly related to their quality of life. Nasal obstruction and sneezing may be the main reasons that affect the quality of life of patients. The allergen level has no significant correlation with the severity of symptoms and quality of life.