氯胺酮对单足致炎大鼠脊髓背角神经元活动的影响

来源 :生理学报 | 被引量 : 0次 | 上传用户：ssssssfs

【摘要】

：

在大鼠脊髓背角用细胞外记录技术共记录到32个单位.角叉菜胶一侧足底注射致炎后, 电刺激该侧足底内外侧神经激动其中A、C纤维时, 脊髓背角神经元的诱发放电数均显著增加; 静

【作者】

：

郭华李菁锦吕国蔚

【机构】

：

首都医科大学神经生物学系

【出处】

：

生理学报

【发表日期】

：

2004年期

【关键词】

：

炎症痛 NMDA受体 windup inflammatory pain NMDA receptor windup

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在大鼠脊髓背角用细胞外记录技术共记录到32个单位.角叉菜胶一侧足底注射致炎后, 电刺激该侧足底内外侧神经激动其中A、C纤维时, 脊髓背角神经元的诱发放电数均显著增加; 静脉注射NMDA受体拮抗剂氯胺酮后, A、C纤维刺激诱发的放电反应均显著下降甚至消失. 致炎后脊髓背角深层单位出现Windup现象, 静脉注射氯胺酮后该现象减轻或消失.结果提示: 角叉菜胶致炎导致脊髓背角神经元兴奋性升高和Windup; NMDA受体参与炎症痛和Windup形成.

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氯胺酮对单足致炎大鼠脊髓背角神经元活动的影响

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