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口腔扁平苔藓(OLP)是一种常见的口腔黏膜慢性炎症性疾病。其发病原因和病理机制至今尚未明确。肿瘤坏死因子α是介导自身免疫反应的重要效应因子,许多研究表明肿瘤坏死因子α在OLP的发生发展过程中起着至关重要的作用。本文从肿瘤坏死因子α与口腔扁平苔藓癌变的关系方面做一综述。
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa. The etiology and pathogenesis has not yet been clarified. Tumor necrosis factor-α (TNF-α) is an important effector of autoimmunity. Many researches show that TNF-α plays a crucial role in the development of OLP. This article reviews the relationship between tumor necrosis factor alpha and carcinogenesis of oral lichen planus.