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作者对6例系统性,2例限局性硬皮病患者作活检,多巴染色,并作了电镜检查,测定黑素体的大小,以研究其皮肤黑素障碍的特征.结果:色素过多的皮肤中,黑素细胞数目正常或仅稍增加,其分布不如正常皮肤规则,其大小、树突数及其长度普遍增加,多巴氧化酶活性较周围正常皮肤为高.在色素脱失的皮肤中,其皮损边缘的黑素细胞较正常的大(3或4倍),且分布不规则,其中一些呈星形或长梭形,其余的呈圆形,无树突.有时其多巴氧化酶较色素过多皮肤还高.皮损中央:未见多巴阳性的黑素细胞.在色素减退的皮肤中,黑素细胞数增加,分布不规则,其细胞大小、树突数
The authors performed biopsy and dopa staining on 6 patients with systemic and 2 localized scleroderma, and underwent electron microscopy to determine the size of melanosomes in order to study the characteristics of their melanocyte dysfunction. Results: hyperpigmentation In the skin, the number of melanocytes is normal or only slightly increased. Its distribution is not as good as that of normal skin. Its size, number of dendrites, and its length are generally increased. Dopa oxidase activity is higher than that of normal surrounding skin. In the skin, the melanocytes at the edge of the lesion are larger (3 or 4 times) than normal, and are irregularly distributed. Some of them are star-shaped or long-spindle-shaped. The others are round and have no dendrites. Sometimes they are numerous. Barium Oxygenase is higher than hyperpigmented skin. Central to skin lesions: No melanocytes with dopa-positive melanocytes. In the hypopigmented skin, the number of melanocytes increases, the distribution is irregular, and the cell size and number of dendrites