Apolipoprotein J: A New Predictor and Therapeutic Target in Cardiovascular Disease?

来源 :中华医学杂志(英文版) | 被引量 : 0次 | 上传用户:q912569130
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective:To review the functional mechanism of apolipoprotein J (apoJ) in the process of atherosclerosis and the feasibility of apoJ as a therapeutic endpoint.Data Sources:Relevant articles published in English from 1983 to present were selected from PubMed.The terms ofatherosclerosis,apolipoprotein J,clusterin (CLU),oxidative stress,and inflammation were used for searching.Study Selection:Articles studying the role of apoJ with atherosclerosis and restenosis after injury were reviewed.Articles focusing on the intrinsic determinants of atherosclerosis were selected.The exclusion criteria of articles were that the studies on immunologic vasculitis.Results:ApoJ,involved in numerous physiological process important for lipid transportation and vascular smooth muscle cell differentiation,including apoptotic cell death,cell-cycle regulation,cell adhesion,tissue remodeling,immune system regulation,and oxidative stress,plays a role in the development of clinical atherosclerosis.In the process of relieving atherosclerosis,apoJ can promote cholesterol and phospholipid export from macrophage-foam cells,and exhibit cytoprotective and anti-inflammatory actions by interacting with lots of known inflammatory proteins which may predict the onset of clinical cardiovascular events and may actually play a causal role in mediating atherosclerotic disease such as C-reactive protein,paraoxonase,and leptin.As known as CLU,apoJ has been identified to play central roles in the process of vascular smooth cells migration,adhesion,and proliferation,which can contribute significantly to restenosis after vascular injury.Conclusions:Intense effort and substantial progress have been made to identify the apoJ that relieves atherosclerosis and vascular restenosis after percutaneous coronary intervention.More work is needed to elucidate the exact mechanisms of and the interrelationship between the actions of apoJ and to successfully achieve regression of atherosclerosis by regarding it as a therapeutic endpoint.
其他文献
随着人们交通出行需求的增加,部分早期修建的高速公路难以满足经济发展的需要,必须进行改建扩建,其中新老桥拼接施工成为一项重点.本文结合工程案例,首先介绍了拼接施工的技
1临床资料患者,男,51岁。以上腹不适伴呕吐半年,呕血一周为主诉入院。患者近半年无无明显诱因出现间断性上腹胀痛伴呕吐症状,进食后加重,自服奥美拉唑钠后症状缓解,未进行系
Background:Researchers initially proposed the substitution of apoptotic chondrocytes in the superficial cartilage by injecting mesenchymal stem cells (MSCs) int
期刊
我厂DHF8—39/450沸腾炉,自1997年1月投运以后,因燃料、操作等原因,一直不能正常运行,平均每周至少停炉一次。点火时,炉料外喷,常引起点火枪皮管爆裂、着火;抽枪时,红料也易
期刊
期刊
@@
流行性腮腺炎是由病毒引起一种急性呼吸道传染病,以腮腺的非化脓性肿胀,坚硬作痛为特征。多有发热和轻度全身不适。偶有并发脑炎,青春发育期又可并发睾丸炎或卵巢炎。该病多发于
各省、自治区、直辖市及计划单列市经贸委(经委、计经委),广电厅(局)、总工会、共青团,国务院有关部门,解放军总后勤部: