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目的探讨肾移植术后重症肺部感染患者HLA-G的表达及临床意义。方法回顾性分析了12例肾移植术后因急性排斥反应血肌酐未降至正常患者,肺部感染后因病情需要停用免疫抑制剂后HLA-G的表达情况及血肌酐的变化。结果12例患者因肾移植术后1次或多次急性排斥,移植肾功能未完全恢复,于术后1～3月出现肺部感染,给予抗炎等治疗,因病情需要停用免疫抑制剂,1周以后患者血肌酐反而逐步下降至正常,且移植肾功能恢复良好。结论肺部感染后HLA-G的上调表达有利于移植肾功能的恢复。
Objective To investigate the expression of HLA-G in patients with severe pulmonary infection after renal transplantation and its clinical significance. Methods We retrospectively analyzed the expression of HLA-G and serum creatinine in 12 patients with renal allograft who did not fall to normal serum creatinine after acute renal transplant recipients. Results 12 patients with acute rejection after one or more renal transplantation, renal transplant function has not fully recovered in 1 to 3 months after the emergence of pulmonary infection, given anti-inflammatory treatment, due to the disease need to disable immunosuppressive agents After 1 week, the serum creatinine gradually decreased to normal, and the function of renal graft recovered well. Conclusion Up-regulated HLA-G expression after lung infection is beneficial to the recovery of renal graft function.