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光学相干层析术(OCT)在人体皮肤病的临床诊断及科学研究方面有着广阔的应用前景。为获得活体状态下人体皮肤形态结构图像及其散射特性参数,研制了一套OCT系统(16μm纵向分辨率,-90 dB的系统灵敏度),应用该系统对人体多个部位的皮肤进行了活体成像,基于扩展的Huygens-Fresnel原理推导了OCT外差信号的表达式,利用该表达式对不同区域的OCT纵向信号曲线段进行线性拟合,提取人体皮肤的散射系数。从获得的结构图像可以清晰地分辨出角质层(掌趾部位)、表皮层、真皮上层等皮肤结构,分析得到了角质层和表皮层的厚度信息以及散射系数。从而验证了OCT用于表层皮肤研究的可行性。
Optical coherence tomography (OCT) in the clinical diagnosis of human skin diseases and scientific research has broad application prospects. In order to obtain morphological images and scattering parameters of human skin under living conditions, a set of OCT system (16μm longitudinal resolution, -90 dB system sensitivity) was developed. The system was applied to the in vivo imaging of human skin Based on the extended Huygens-Fresnel principle, the expression of OCT heterodyne signal is deduced. Using this expression, the OCT longitudinal signal curve segments in different regions are linearly fitted and the scattering coefficient of human skin is extracted. From the obtained structural images, the skin structure of the stratum corneum (the toe part), the epidermis and the upper dermis can be clearly distinguished, and the thickness information and the scattering coefficient of the stratum corneum and the epidermis are obtained. Thus verifying the feasibility of using OCT for topical skin studies.