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目的 :考察祛白酊中君药补骨脂有效成分补骨脂素和异补骨脂素的透皮效果。方法 :采用简单小室法 ,以离体大鼠皮肤为透皮屏障 ,用双波长薄层扫描法测定体外接收液中补骨脂素和异补骨脂素的含量 ,进而计算累积透皮量和透皮率 ,并与未加月桂氮酮和二甲基亚砜的祛白酊透皮效果进行了实验性比较。结果 :补骨脂素的 8h累积透皮量与透皮率分别为 (92 6 5±2 91) μg·ml-1和 (84 6 6± 2 6 6 ) % ,异补骨脂素的 8h累积透皮量与透皮率分别为 (86 37± 2 6 7) μg·ml 1和 (82 2 9± 2 5 4 ) % ,与未加月桂氮酮和二甲基亚砜制剂的透皮效果比较 ,有显著性差异 (P <0 0 1)。结论 :祛白酊的透皮效果良好
Objective: To investigate the transdermal effect of psoralen and isopsoralen, the effective components of the medicinal psoralen in Qu Bai tincture. Methods: Using simple chamber method, the rat skin was taken as the transdermal barrier. The contents of psoralen and isopsoralen in the in vitro receiving fluid were determined by two-wavelength thin-layer scanning. Then the cumulative transdermal dose and Transdermal rate, and with non-lauric azanone and dimethyl sulfoxide quercetin transdermal effect of the experimental comparison. Results: The cumulative transdermal penetration and percutaneous permeability of psoralen at 8h were (92 6 5 ± 2 91) μg · ml -1 and (84 6 6 ± 26 6)%, respectively. The cumulative transdermal and transdermal rates were (86 37 ± 2 6 7) μg · ml 1 and (82 29 ± 2 54)%, respectively, compared with those without laurocapram and dimethylsulfoxide Skin effects were significantly different (P <0.01). Conclusion: Qu Bai tincture transdermal effect is good