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目的探讨非小细胞肺癌(NSCLC)螺旋CT(spiral CT,SCT)表现特征与病人血清中可溶性Fas(soluble Fas,sFas)和FasL(soluble FasL,sFasL)之间的关系。方法对32例经SCT扫描的并经病理证实的非小细胞肺癌进行回顾性分析,采用双抗体夹心酶联免疫吸附法(ELISA)检测其血清中sFas和sFasL水平,并将非小细胞肺癌的CT表现特征与检测结果进行对照分析。结果病人血清中sFas和sFasL检测水平与肿瘤的类型、大小无统计学意义(P>0.05);与有无纵隔淋巴结肿大,是否累及胸膜或心包膜,肿瘤是否有毛刺、结节和分叶,是否存在胸腔积液和肺不张等均有统计学差异(P<0.05)。结论SCT的表现特征在一定程度上可反映肺癌病人血清中sFas和sFasL的水平。
Objective To investigate the relationship between the characteristics of spiral CT (SCT) and soluble Fas (sFas) and soluble FasL (sFasL) in patients with non-small cell lung cancer (NSCLC). Methods A retrospective analysis was performed on 32 cases of pathologically confirmed non-small cell lung cancer with SCT scanning. The levels of sFas and sFasL in serum were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and the serum levels of sFas and sFasL in non-small cell lung cancer CT performance characteristics and test results were analyzed. Results The levels of sFas and sFasL in the serum of the patients were not significantly different from those of the tumors (P> 0.05), with or without mediastinal lymph nodes, whether the pleura or pericardium was involved, whether the tumor had burr, nodules and Leaf, the presence of pleural effusion and atelectasis were statistically different (P <0.05). Conclusion The features of SCT may reflect the levels of sFas and sFasL in serum of patients with lung cancer to some extent.