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目的观察α-硫辛酸(ALA)对糖尿病周围神经病变(DPN)的疗效及安全性。方法选择符合诊断标准的64例患者随机分为治疗组与对照组,治疗组(n=34):ALA 600 mg加入生理盐水250 ml中静滴,1次/d;对照组(n=30):丹参20 ml加入生理盐水250 ml中静滴,1次/d;疗程均为3周,观察治疗前后两组血糖、血脂、临床症状、肌电图神经传导速度的变化情况。结果两组血糖、血脂变化无明显差异。治疗组TSS评分较治疗前显著降低(P<0.01),且患者的麻木、疼痛、烧灼感等感觉性症状评分也比治疗前和对照组明显降低(P<0.01)。治疗组患者总体满意度为91.2%,而对照组仅16.7%对疗效满意(P<0.01)。结论 ALA可有效改善2型糖尿病患者的周围神经病变,且无不良反应。
Objective To observe the efficacy and safety of α-lipoic acid (ALA) on diabetic peripheral neuropathy (DPN). Methods Sixty-four patients who met the diagnostic criteria were randomly divided into treatment group (n = 34): control group (n = 30), ALA 600 mg and normal saline 250 ml, : Salvia 20 ml added saline 250 ml intravenous infusion, 1 / d; course of treatment were 3 weeks, before and after treatment to observe the blood glucose, blood lipid, clinical symptoms, EMG nerve conduction velocity changes. Results There was no significant difference in blood glucose and blood lipid between the two groups. The TSS score of the treatment group was significantly lower than that before treatment (P <0.01), and the score of sensory symptoms such as numbness, pain and burning were significantly lower than those before treatment and the control group (P <0.01). Overall satisfaction was 91.2% in the treatment group, while only 16.7% in the control group was satisfactory (P <0.01). Conclusion ALA can effectively improve peripheral neuropathy in patients with type 2 diabetes without adverse reactions.