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本实验选用日本大耳白家兔５２只，观察了清开灵液对白细胞致热源（ｌｅｕｃｏｃｙｔｉｃｐｙｒｏ－ｇｅｎ，ＬＰ）性发热效应及脑脊液（ＣＳＦ）中ｃＡＭＰ含量变化的影响。结果显示：（１）清开灵液对家兔正常体温的影响与正常对照组相比没有明显的差异（Ｐ＞０．０５）。（２）单独注射ＬＰ引起直肠温度上升０．９３±０．２０℃（△Ｔ），体温反应指数（ＴＲＴ＿４）为１．９０±０．５１。ＬＰ＋清开灵组，静脉注射ＬＰ半小时前肌肉注射清开灵液，△Ｔ为０．４６±０．１４℃；ＴＲＩ＿４为０．８６±０．２１，与单独注射ＬＰ组比较差异非常显著（Ｐ＜０．００１），说明清开灵液有明显的解热作用。（３）静脉注射ＬＰ１ｈ时，检测兔ＣＳＦ中ｃＡＭＰ含量为２４．７５±３．７４ｐｍｏｌ／ｍｌ，而ＬＰ＋清开灵组ｃＡＭＰ含量为１８．２５±１．００ｐｍｏｌ／ｍｌ，两组相比差异非常显著（Ｐ＜０．０１）。同时发现清开灵液有使正常家兔ＣＳＦ中ｃＡＭＰ含量下降的趋势。各组体温变化与ＣＳＦ中ｃＡＭＰ含量变化呈显著正相关（ｒ＝０．９８４２，Ｐ＜０．０５）。本实验结果表明，清开灵液不仅抑制ＬＰ引起的发热反应，而且明显降低ＬＰ引起的ＣＳＦ中ｃＡＭＰ含量的增多。作者推论：清开灵液的?
In this experiment, 52 Japanese white rabbits were selected to observe the effect of Qingkailing solution on leucocytic pyro-gen (LP) fever and cAMP content in cerebrospinal fluid (CSF). The results showed that: (1) The effect of Qingkailing solution on normal body temperature in rabbits was not significantly different from that in the normal control group (P>0.05). (2) LP injection alone increased the rectal temperature by 0.93±0.20°C (△T), and the body temperature response index (TRT_4) was 1.90±0.51. In LP+Qingkailing group, intramuscular injection of Qingkailing injection was performed half an hour after intravenous injection of LP. The △T was 0.46±0.14°C; TRI_4 was 0.86±0.21, which was significantly different from the LP group alone. (P<0.001), indicating that Qingkailing has obvious antipyretic effects. (3) The cAMP content in rabbit CSF was 24.75±3.74pmol/ml when LP1h was injected intravenously, while the cAMP content was 18.25±1.00pmol/ml in LP+ QingKaiLing group. Significant (P < 0.01). At the same time, it was found that Qingkailing had the tendency of decreasing cAMP content in normal rabbit CSF. There was a significant positive correlation between changes in body temperature and changes in cAMP content in CSF (r=0.9842, P<0.05). The results of this experiment show that Qingkailing solution not only inhibits the fever reaction caused by LP, but also significantly reduces the increase of cAMP content in CSF caused by LP. The author reasoning: Qingkai Ling liquid?