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以拟南芥Arabidopsis thaliana等植物为主要对象,系统评述了乙酰乳酸合成酶(ALS)抑制剂在作用靶标、选择性机制、毒性机理及化学杀雄作用等方面的研究进展。ALS是磺酰脲类、咪唑啉酮类等多种除草剂的共同作用靶标,最新研究又发现苯磺隆、酰嘧磺隆等多种ALS抑制剂可作为敏感植物的化学杀雄剂。目前该研究领域的薄弱环节是ALS抑制剂的毒性机理,先后提出了支链氨基酸饥饿、核酸合成受阻、ALS底物积累、养分转运障碍、无氧呼吸等假说,但均未能被证实。借助高通量的代谢组学、转录组学、蛋白质组学检测技术将能够更全面地揭示ALS抑制剂的生理生化效应,为研究其毒性机理提供新证据。
The Arabidopsis thaliana Arabidopsis thaliana and other plants as the main object, the system review of acetolactate synthase (ALS) inhibitors in the role of target, the mechanism of selectivity, toxicity and chemical killing effect and so on research progress. ALS is a sulfonylurea, imidazolinones and other herbicides co-target, the latest study also found that tribenuron and amidosulfuron and other ALS inhibitors can be used as a sensitive plant chemical maleicide. At present, the weak link in this research area is the toxic mechanism of ALS inhibitors. The hypothesis of starvation of branched-chain amino acids, blocked nucleic acid synthesis, accumulation of ALS substrate, nutrient transport disorder and anaerobic respiration has been proposed. With high-throughput metabolomics, transcriptomics and proteomics detection technology will be able to reveal the physiological and biochemical effects of ALS inhibitors more completely and provide new evidence for the study of its toxicity mechanism.