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本文实验用大肠杆菌内毒素两次静脉注射法初步成功地制作了家兔温病邪入血分之热瘀气脱证动物模型。通过血液学、病理形态学、血液流变学等指标的对照观察,表明热瘀气脱证动物的病理实质为急性DIC,病变特征为低粘度血症、低凝状态、血细胞聚集。文中根据这些与既往研究截然不同的实验资料指出:热瘀气脱是热入血分的一个特殊而严重的证型,施治应与血分阶段的其它证型严格区别。并就中医特别是温病学动物造模研究的思路问题;在模拟临床疾病模型的基础上制作中医证模型的意义问题;卫气营血造模研究应着眼于“四期”中的具体证型,而不应着眼于笼统的卫气营血四证本身问题等,提出了自己的初步看法。
In this paper, two intravenous injection method of E. coli endotoxin was initially successfully produced rabbit warm febrile disease into the blood points of the animal model of stasis. Through the hematology, pathomorphology, hemorheology and other indicators of the control observation, indicating that the physical essence of hot stasis gas evidentiary animal acute DIC, lesions characterized by low viscosity, low coagulation state, blood cell aggregation. According to these experimental data which are totally different from the previous studies, it is pointed out that hot stasis is a special and serious syndrome of hot blood stasis, which should be strictly distinguished from other syndromes of blood staging. And on the TCM especially warm animal studies of animal modeling ideas; in the simulation of clinical disease model based on the significance of making TCM model; Wei Qi Ying blood modeling should focus on the “four” in the specific card Type, rather than focusing on the general Wei Qi Ying Zheng four blood card itself issues, put forward their own initial views.