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Objective: To evaluate the efficacy and safety of XuanFei TongFu method in the treatment of sepsis. Methods: The relevant literatures on the treatment of sepsis by Xuanfei Tongfu method, published by PubMed, Medline and the Cochrane library, CNKI, WEIPU Database,WANFANG Database until December 2019 were searched by computer. Revman 5.3 was used to analyze the relevant literatures that met the inclusion and exclusion criteria, and to evaluate the influence of Xuanfei Tongfu method on gastrointestinal function, adverse reactions of gastrointestinal, 28 day mortality. Results: a total of 17 randomized controlled clinical trials (RCTS) involving a total of 984 patients were included. Xuanfei Tongfu decoction combined with the control group can improve intestinal function. Xuanfei Tongfu decoction can reduce gastrointestinal adverse reactions, but there is no statistical significance, and reducing mortality of 28 days (RR= 0.64,95％CI(0.42,0.99),P=0.04), reducing the APACHE Ⅱ[SMD=-0.90, 95％CI(-1.49, -0.31), P=0.0003], reducing of Il-6[SMD=-0.36, 95％CI(-0.62, -0.1), P=0.007], and improving IL-10 were all better than the control group, the difference was statistically significant. Conclusion: The method of Xuanfei Tongfu can enhance the gastrointestinal function, reduce the gastrointestinal adverse reactions, and improve the prognosis of sepsis patients. It may be achieved by regulating the body's immune inflammatory response.