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目的探讨ＥＧＦｍＲＮＡ的表达与胰腺癌发生、发展及预后的关系．方法应用Ｎｏｒｔｈｅｒｎｂｌｏｔ杂交方法，检测胰腺癌２７例和正常胰组织７例中ＥＧＦｍＲＮＡ表达．结果正常胰腺组织７例未检测到ＥＧＦｍＲＮＡ表达，胰腺癌２７例ＥＧＦｍＲＮＡ阳性表达率６６７％（１８例），经卡方检验发现，ＥＧＦｍＲＮＡ表达与胰腺癌病理分级、临床分期及伴随局部淋巴结转移呈显著相关（Ｐ＜００５）．结论ＥＧＦｍＲＮＡ表达与胰腺癌发生有关，胰腺癌ＥＧＦｍＲＮＡ表达可作为胰腺癌预后的参考指标
Objective To investigate the relationship between the expression of EGF mRNA and the occurrence, development and prognosis of pancreatic cancer. Methods Northern blot hybridization was used to detect the expression of EGF mRNA in 27 cases of pancreatic cancer and 7 cases of normal pancreas. Results EGF mRNA expression was not detected in 7 normal pancreatic tissues. The positive expression rate of EGF mRNA in 27 pancreatic cancer cases was 66.7% (18 cases). The expression of EGF mRNA and pancreatic cancer pathological grade, clinical stage and regional lymph node metastasis were found by chi-square test. Significantly related (P<005). Conclusion The expression of EGF mRNA is related to the occurrence of pancreatic cancer. The expression of EGFmR NA in pancreatic cancer can be used as a reference index for the prognosis of pancreatic cancer.