近年来由于结核杆菌基因突变及抗结核药物研制相对滞后等原因,国内外结核病发病率及病死率都呈逐渐增高趋势。我国是世界上22个结核病高负担国家之一[1],结核病患者数量居世界第二位,给社会带来沉重的负担。结核性脑膜炎(TBM)是结核病最严重的类型,在我国也是常见病,具有病死率 In recent years, due to mutations in Mycobacterium tuberculosis and the relatively lagging development of anti-TB drugs and other reasons, the morbidity and mortality of tuberculosis both at home and abroad are gradually increasing. China is one of the 22 countries with a high burden of tuberculosis in the world [1], and the number of tuberculosis patients ranks second in the world, putting a heavy burden on the society. Tuberculous meningitis (TBM) is the most serious type of tuberculosis, is also a common disease in our country, with a mortality