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目的研究新生儿缺血缺氧性脑病(HIE)神经元特异性烯醇化酶(NSE)的变化,探讨它们对HIE患儿病情进展、病情程度、预后判断的价值。方法符合新生儿HIE诊断标准的病例39例,分为轻度HIE组和中重度HIE组,选取同时期出生健康新生儿为对照组,采用酶联免疫法对新生儿不同时间的血清NSE浓度进行测定,并对结果进行统计学分析。结果新生儿血清NSE浓度与新生儿HIE相关,且与其严重程度正相关,组间差异具有显著性统计学意义(P<0.05)。结论血清中NSE水平可作为判断新生儿HIE和脑损伤程度的可靠指标。
Objective To study the changes of neonatal hypoxic-ischemic encephalopathy (HIE) neuron-specific enolase (NSE), and to explore the value of them on the progression of disease, the severity of disease and the prognosis of children with HIE. Methods Thirty-nine neonates with HIE diagnostic criteria were divided into mild HIE group and moderate-severe HIE group. The healthy newborn infants in the same period were selected as the control group. Serum NSE concentrations at different time points were measured by enzyme-linked immunosorbent assay Determination, and the results of a statistical analysis. Results Neonatal serum NSE concentration was correlated with neonatal HIE, and positively correlated with its severity. The difference between the two groups was statistically significant (P <0.05). Conclusion Serum NSE level can be used as a reliable indicator to judge the degree of neonatal HIE and brain injury.