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本文报导用采自轻度马尾松毛虫病流行区的马尾松毛虫,取其毒毛胸段,捣碎制成无菌滤液,对小白鼠和家兔进行各种致病途径的研究.用0.1毫升滤液(约含一条松毛虫毒素量)分别给小白鼠作皮下、肌肉和腹腔注射,结果关节反应动物数依次为45.00％、26.32％和22.22％,并经病理学检查证实其病理反应与以往报导的经皮肤接触所致病变相同,表明注射途径同样可使实验动物发病.这将为进一步研究松毛虫病的致病机理和防治提供实验方法的依据.本实验还观察了用滤液灌胃和滴眼途径对小白鼠和家兔的致病作用,结果均未能引起实验动物发病,初步认为马尾松毛虫毒素经消化道和眼结合膜不产生致病作用.
This paper reports on the use of pine caterpillars collected from the endemic areas of mild pine mass caterpillar disease to take their toxic hair thoracic segments and mash them into sterile filtrates to study various pathogenic pathways in mice and rabbits. 0.1 ml of filtrate (containing about one dose of pine caterpillar) was injected into the mice subcutaneously, intramuscularly and intraperitoneally. The number of joint reaction animals was 45.00%, 26.32% and 22.22%, respectively, and the pathological response was confirmed by pathological examination. The same lesions caused by skin contact have been reported in the past, indicating that the injection route can also cause the onset of experimental animals. This will provide the basis for further research on the pathogenic mechanism and prevention of pine caterpillar disease. This experiment also observed the use of filtrate irrigation. The pathogenic effects of stomach and eye drops on mice and rabbits did not cause the disease in experimental animals. It was initially believed that the pine worm caterpillar toxins did not produce pathogenic effects through the digestive tract and eye conjugation membrane.