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目的:研究β-环糊精(β-CD)包合中药复方愈溃胶囊中挥发油的最佳工艺。方法:采用饱和水溶液法制备包合物,通过正交试验设计对包合工艺条件进行优选,并采用差示量热扫描法、热重分析法和红外光谱法对包合物进行表征。结果:最佳包合工艺条件是挥发油(mL)-β-CD(g)1∶10,包合温度50℃,包合时间2 h,表征分析显示挥发油被β-CD成功包合。结论:优选的包合工艺操作简便、工艺稳定、挥发油包合率和包合物得率较高。
Objective: To study the best technology of β-cyclodextrin (β-CD) for inclusion of volatile oil in traditional Chinese medicine Yufu capsule. Methods: The inclusion complex was prepared by the method of saturated aqueous solution. The orthogonal design was used to optimize the inclusion process. The inclusion complex was characterized by differential scanning calorimetry, thermogravimetric analysis and infrared spectroscopy. Results: The optimum inclusion conditions were as follows: volatile oil (mL) -β-CD (g) 1:10, inclusion temperature 50 ℃, inclusion time 2 h, characterization analysis showed that the essential oil was successfully encapsulated by β-CD. Conclusion: The optimal inclusion process is simple and convenient, the process is stable, the inclusion rate of volatile oil and inclusion compound are higher.