引起药物性肝损害的药物早已发现的有600余种,随着新的药物的投入使用其也在增加。现将引起肝损害的常见药物与临床表现简要叙述如下。1 抗生素类 陈凤云报道氨苄青霉素引起肝损害8例,其中两例死亡。有报道用药1周后1/4患者S—GPT升高。其他如羧苄青霉素、邻氯青霉素、氟氯青霉素、苯唑青霉素等均可轻度损害肝脏。头孢菌素类如头孢立新、头孢氨苄可致黄疸和肝坏死。王鸣声报道了庆大霉素致 More than 600 species of drugs that have caused drug-induced liver damage have been found and are also increasing with the introduction of new drugs. Now common cause of liver damage and clinical manifestations of drugs are briefly described below. An antibiotic Chen Fengyun reported ampicillin caused liver damage in 8 cases, of which two died. It has been reported 1/4 weeks after the patient’s S-GPT increased. Others, such as carbenicillin, o-chlorpheniramine, flucloxacillin, oxacillin and so on, can mildly damage the liver. Cephalosporins such as cefazolin, cephalexin can cause jaundice and liver necrosis. Wang Ming Sheng Gentamicin reported