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目的 探讨2型糖尿病患者血脂水平与糖尿病性黄斑水肿的关系。方法 观察资料来自我院对1576例参加糖尿病并发症筛查的病例进行眼底和全身检查,同时测定了血脂和其他与糖尿病有关的血液生化指标。结果 黄斑水肿者101例(黄斑水肿组),占所有糖尿病患者的6.4％,非增殖性糖尿病视网膜病变患者的20.50％,增殖性糖尿病性视网膜病变的39.22％。黄斑水肿组各项血脂参数均高于无黄斑水肿组(胆固醇P<0.01,其他指标P<0.05)。高胆固醇组黄斑水肿的发病率为7.77％,胆固醇正常组为4.98％,增加约为50％。血脂以外的因素仅血压的收缩压差异显著,黄斑水肿组平均收缩压在正常范围,但高于无黄斑水肿组。结论 本研究表明血浆脂质水平升高与增加糖尿病性黄斑水肿的发生率有关。糖尿病控制不佳,高血脂和高血压的存在可能是2型糖尿病患者易于发生黄斑水肿的原因。
Objective To investigate the relationship between lipid levels and diabetic macular edema in type 2 diabetic patients. Methods Data from our hospital were collected from 1576 diabetic complications in our hospital for fundus examination and whole body examination. Blood lipid and other blood biochemical markers related to diabetes were also determined. Results There were 101 cases of macular edema (macular edema group), accounting for 6.4% of all diabetic patients, 20.50% of non-proliferative diabetic retinopathy and 39.22% of proliferative diabetic retinopathy. All lipid parameters of macular edema group were higher than those without macular edema (cholesterol P <0.01, other indexes P <0.05). The incidence of macular edema in hypercholesterolemic group was 7.77% and in normal cholesterol group was 4.98%, an increase of about 50%. Blood pressure factors other than blood pressure systolic blood pressure was significantly different, macular edema average systolic blood pressure in the normal range, but higher than no macular edema group. Conclusions This study shows that elevated plasma lipid levels are associated with an increased incidence of diabetic macular edema. Poorly controlled diabetes, the presence of hyperlipidemia and high blood pressure may be responsible for macular edema in patients with type 2 diabetes.