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为探讨不同剂量心肌肽对小鼠的抗氧化作用,分别以低、中、高[120、230、690 mg/(kg·d)]三个剂量的心肌肽给予小鼠连续灌胃20 d,对照组灌胃蒸馏水0.2 ml/d,20 d后测定小鼠的负重力竭游泳时间、定量运动负荷后的肝糖原(Gn)含量、血浆尿素氮(BUN)含量、股四头肌超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果显示,低、中、高剂量组小鼠的负重力竭游泳时间均不同程度延长,运动后BUN含量降低、肝Gn含量提高,且呈现剂量-反应关系。低、中、高剂量心肌肽均显著增加运动后股四头肌SOD活性,减少股四头肌MDA含量,且呈剂量-反应关系。负重力竭游泳时间与SOD活性呈正相关,与MDA含量呈负相关。提示心肌肽作为一种新型抗疲劳营养补剂具有重要的应用前景。
In order to investigate the anti-oxidative effects of different doses of myocardial peptide on mice, mice were given intragastric administration of three doses of myocardial peptide (120,230,690 mg / (kg · d)] for 20 days, The control group was fed with 0.2 ml / d of distilled water. After 20 days, the rats were sacrificed and their swimming time was determined. The hepatic glycogen (Gn) content, blood urea nitrogen (BUN) content, The activity of SOD and the content of malondialdehyde (MDA) The results showed that the mice in low, middle and high dose groups had prolonged exhaustion and exhaustive swimming time, decreased BUN content and increased hepatic Gn content after exercise, showing a dose-response relationship. Low, medium and high dose of myocardial peptide significantly increased exercise quadriceps SOD activity, decreased quadriceps MDA content, and a dose-response relationship. There was a positive correlation between exhaustive swimming time and SOD activity, and a negative correlation with MDA content. Suggest that myocardial peptide as a new anti-fatigue nutritional supplements has an important application prospect.