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氧氟沙星(OFX)和环丙沙星(CPX)是广泛应用的抗菌药。体内外实验表明两药对分枝杆菌包括结核分枝杆菌和鸟型分枝杆菌有抗菌活性。本文回顾性评价了两药长期治疗分枝杆菌感染的安全性。 1986～1992年的7年中共收治656例分枝杆菌感染的病人,其中103例用了OFX和CPX,而单用OFX者26例,单用CPX者65例,用过两药但不是同时使用者6例,故按用OFX者32例、用CPX者71例进行评价。人群资料表明,CPX主要用于治疗
Ofloxacin (OFX) and ciprofloxacin (CPX) are widely used antibacterials. In vitro and in vivo experiments show that the two drugs have antibacterial activity against mycobacteria, including Mycobacterium tuberculosis and Mycobacterium avium. This article retrospectively evaluated the safety of long-term treatment of two drugs Mycobacterium infection. Between 1986 and 1992, 656 patients with mycobacterial infections were treated in 7 years, of whom OFX and CPX were used in 103, 26 in OFX alone and 65 in CPX alone. However, both drugs were used but not concurrently 6 cases, so by OFX in 32 cases, with CPX in 71 cases were evaluated. Population data show that CPX is mainly used for treatment