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目的:探讨子宫内膜轻创术对拮抗剂方案体外受精-胚胎移植临床妊娠率、胚胎种植率和活产率的影响。方法:回顾性分析2007年1月～2009年12月在该院生殖中心行拮抗剂方案体外受精-胚胎移植(IVF-ET)治疗的不孕症患者,促性腺激素(Gn)启动日B超显示子宫内膜回声异常或内膜厚度>5 mm的患者共69例,其中28例行子宫内膜轻创术者为研究组,41例未行轻创术者为对照组,比较两组患者临床妊娠率、胚胎种植率和活产率的差别。结果:两组患者平均年龄、不孕年限、基础FSH水平、Gn启动剂量、Gn使用天数、Gn总量、HCG日血E2水平、获卵数、受精数、可移植胚胎数和移植胚胎数均无统计学差异(P>0.05),研究组患者临床妊娠率、胚胎种植率和活产率分别为50.00%、28.13%和46.43%,虽然高于对照组的41.46%、23.47%和31.71%,但无统计学差异(P>0.05)。结论:子宫内膜轻创术并不能改善拮抗剂方案体外受精-胚胎移植的治疗结局。
Objective: To investigate the effect of endometrial minimally invasive surgery on clinical pregnancy rate, embryo implantation rate and live birth rate of the IVF-ET program. Methods: The infertility patients who underwent IVF-ET with antagonist regimen from January 2007 to December 2009 in Reproductive Center of the hospital were retrospectively analyzed. A total of 69 patients showed endometrial echogenic or endometrial thickness> 5 mm, of which 28 patients underwent endometrial minimally invasive surgery as study group and 41 patients underwent minimally invasive surgery as control group. Patients in two groups The difference between clinical pregnancy rate, embryo implantation rate and live birth rate. Results: The average age, duration of infertility, basal FSH level, Gn priming dose, days of Gn use, total Gn level, E2 level of HCG day, number of oocytes retrieved, number of fertilization, number of transplanted embryos and number of transplanted embryos The clinical pregnancy rate, embryo implantation rate and live birth rate in study group were 50.00%, 28.13% and 46.43% respectively, which were higher than those in control group (41.46%, 23.47% and 31.71%, respectively) But no statistical difference (P> 0.05). CONCLUSIONS: Endometrial minimally invasive surgery does not improve the outcome of IVF-ET treatment.