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目的探讨多烯磷脂胆碱联合葛根素对非酒精性脂肪肝(non-alcoholic fatty liver disease NAFLD)患者血清中IL-6、IL-8、TNF-α表达水平的影响。方法本研究于2010年12月—2013年6月将100例NAFLD患者随机分为对照组、多烯磷脂胆碱组、葛根素组和联合治疗组。治疗4周后,检测各组患者ALT、AST、IL-6、IL-8、TNF-α水平,并进行比较。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观治疗后各组患者血清ALT、AST、IL-6、IL-8、TNF-α水平较治疗前显著下降(P<0.05),对照组、多烯磷脂胆碱组、葛根素组之间比较无显著性差异,联合治疗组较对照组、多烯磷脂胆碱组、葛根素组显著下降(P<0.05)。结论多烯磷脂胆碱联合葛根素治疗NAFLD患者,能够显著降低患者血清中ALT、AST、IL-6、IL-8、TNF-α水平,从而改善患者肝功能。
Objective To investigate the effects of polyenephospholipid choline and puerarin on the serum IL-6, IL-8 and TNF-α levels in patients with non-alcoholic fatty liver disease (NAFLD). Methods From December 2010 to June 2013, 100 NAFLD patients were randomly divided into control group, polyenephospholipid choline group, puerarin group and combination therapy group. After 4 weeks of treatment, the levels of ALT, AST, IL-6, IL-8 and TNF-α in each group were detected and compared. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the levels of ALT, AST, IL-6, IL-8 and TNF-α in serum of patients in each group were significantly lower than those before treatment (P <0.05); between control group, polyenephospholipid choline group and puerarin group Compared with the control group, the polyenephospholipid choline group and the puerarin group decreased significantly (P <0.05). CONCLUSION: Polyene phospholipid choline combined with puerarin in patients with NAFLD can significantly reduce the levels of ALT, AST, IL-6, IL-8 and TNF-α in the serum of patients with NAFLD to improve the liver function.