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目的观察沙利度胺治疗外周关节型强直性脊柱炎的临床疗效。方法外周关节型强直性脊柱炎患者65例,随机分成两组,治疗组35例给予沙利度胺治疗,对照组30例给予甲氨蝶呤治疗。结果治疗组总有效率为91.43%,对照组总有效率为86.67%,两组差异无统计学意义(P>0.05);两组治疗前后各项指标均显著改善,差异有统计学意义(P<0.05或P<0.01),治疗组患者晨僵时间、红细胞沉降率、C反应蛋白改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论沙利度胺治疗强直性脊柱炎效果显著,安全、可靠,值得临床推广使用。
Objective To observe the clinical efficacy of thalidomide in the treatment of peripheral joint ankylosing spondylitis. Methods 65 patients with peripheral joint ankylosing spondylitis were randomly divided into two groups. 35 patients in the treatment group were treated with thalidomide, and 30 patients in the control group were treated with methotrexate. Results The total effective rate was 91.43% in the treatment group and 86.67% in the control group, with no significant difference between the two groups (P> 0.05). The indexes before and after treatment in both groups were significantly improved (P <0.05 or P <0.01). The improvement of morning stiffness, erythrocyte sedimentation rate and C-reactive protein in the treatment group were significantly better than those in the control group (P <0.05). Conclusion Thalidomide treatment of ankylosing spondylitis effect is significant, safe and reliable, it is worth promoting the use of the clinic.