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目的 通过比较面神经炎患者与正常对照之间的抗水痘 带状疱疹病毒抗体滴度的差异以及面神经炎患者在不同疾病阶段的抗水痘 带状疱疹病毒抗体滴度变化 ,探讨抗水痘 带状疱疹病毒抗体与面神经炎之间的关联。方法 用酶标记葡萄球菌A蛋白 (SPA)染色法对 11例面神经炎患者及 2 6例正常人血清中抗水痘 带状疱疹病毒 (VZV)抗体进行检测 ,还对其中 6名患者进行了发病早期及 2周后的血清抗VZV抗体检测。结果 面神经炎患者组的抗VZV抗体滴度显著高于对照组 (P <0 .0 5 ) ;在 6例患者的不同疾病阶段测得的抗体滴度中 ,3例患者在发病 2周后抗体滴度比发病初期增加 4倍以上 ,1例增加 2倍 ,2例无改变。结论 抗VZV抗体滴度与面神经炎的发病相关 ,提示VZV感染可能是面神经炎的致病因素之一。
Objective To compare the titer of anti-varicella zoster virus antibody between patients with facial neuritis and normal controls and the anti-varicella-zoster virus antibody titers in patients with facial neuritis at different stages of disease, The link between antibodies and facial neuritis. Methods Serum anti-varicella zoster virus (VZV) antibodies were detected in 11 patients with facial neuritis and 26 normal individuals by enzyme-linked immunosorbent assay (Staphylococcus aureus protein A (SPA)). Six of the patients were also diagnosed early And serum anti-VZV antibody test after 2 weeks. Results The anti-VZV antibody titers of patients with facial neuritis were significantly higher than those of the control group (P <0.05). Among the antibody titers measured at different disease stages of 6 patients, 3 patients developed anti-VZV antibody two weeks after the onset of disease Titers increased more than 4 times earlier than the onset, 1 case increased 2-fold, 2 cases without change. Conclusion Anti-VZV antibody titers are associated with the pathogenesis of facial neuritis, suggesting that VZV infection may be one of the causative agents of facial neuritis.