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目的 :探讨早期使用静脉注射丙种球蛋白 (IVIG)对预防或减轻新生儿 ABO溶血病发生高胆红素血症和贫血的效果。方法 :取脐血作血清学检查以判断 ABO溶血病 ,对脐血总胆红素达 2 5 .5 μm ol/ L 以上新生儿于出生 48小时内用IVIG80 0 mg/ kg· d,定时检测末梢血红细胞 (RBC) ,血红蛋白 (Hb)红细胞压积 (HCT) ,静脉血总胆红素 ,并与对照组对比。结果 :IVIG组在总胆红素水平 ,光疗时间 ,黄疸消退时间均显著低于对照组 (P<0 .0 1) ;RBC、Hb、HCT高于对照组 (0 .0 5 >P>0 .0 1)。作自身对照 IVIG组治疗前后 RBC、 Hb、 HCT无明显变化 (P>0 .0 5 ) ,对照组显著下降 (P<0 .0 1)。结论 :早期使用 IVIG可有效地防止或减轻由新生 ABO溶血病引起的高胆症和贫血。
Objective: To investigate the effect of intravenous gamma globulin (IVIG) on the prevention or reduction of hyperbilirubinemia and anemia in neonates with ABO hemolytic disease. Methods: The umbilical cord blood was taken for serological examination to determine ABO hemolytic disease. The newborns with cord blood total bilirubin up to 25.5 μmol / L were treated with IVIG80 0 mg / kg · d within 48 hours of birth, Peripheral blood red blood cells (RBC), hemoglobin (Hb) hematocrit (HCT), venous total bilirubin, and compared with the control group. Results: The levels of total bilirubin, phototherapy time and jaundice in IVIG group were significantly lower than those in control group (P <0.01); RBC, Hb and HCT were higher than those in control group (0. 05> P> 0 .0 1). There were no significant changes in RBC, Hb and HCT before and after treatment in IVIG group (P> 0.05), but decreased in control group (P <0.01). CONCLUSIONS: Early use of IVIG effectively prevented or attenuated hypercholesteremia and anemia caused by neonatal ABO hemolytic disease.