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目的:观察补肾健脾方联合CEF化疗方案择时用药在乳腺癌术后患者的临床疗效。方法:50例乳腺癌术后患者随机分为观察组(化疗药物在01:00~03:00时注入,中药健脾方于每日09:00~11:00时服用,中药补肾方于每日17:00~19:00时服用)和对照组(化疗药物在日间注入,中药补肾及健脾方于每日日间服用)各25例,观察完成治疗疗程后患者的生活质量、不良反应发生情况及脾肾虚状态。结果:观察组患者的生活质量,不良反应和脾肾虚状态均明显优于对照组,组间比较,差异具有统计学意义(P<0.05)。结论:中药补肾健脾方联合CEF化疗方案时辰治疗可提高化疗疗效并降低化疗毒副作用,优于常规使用CEF化疗方案及中药。
Objective: To observe the clinical efficacy of Bushen Jianpi Fang combined with CEF chemotherapy regimen in postoperative patients with breast cancer. Methods: Fifty patients with postoperative breast cancer were randomly divided into observation group (chemotherapy drugs were injected at 01: 00 ~ 03: 00, Chinese medicine spleen prescription was taken daily at 09: 00-11: 00, Day 17: 00 ~ 19: 00) and the control group (chemotherapy drugs injected during the day, traditional Chinese medicine kidney and spleen side taken daily daily) 25 cases of each patient to observe the quality of life after treatment, poor Response and spleen and kidney deficiency status. Results: The quality of life, adverse reactions and the status of spleen and kidney in the observation group were significantly better than those in the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion: The Chinese medicine Bushenjianpi Recipe combined with CEF chemotherapy regimen can improve the curative effect of chemotherapy and reduce the side effects of chemotherapy, which is better than the conventional CEF chemotherapy regimen and traditional Chinese medicine.