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本文将45只表浅麻醉大白鼠分为冰浴刺激组(冰浴组)、异搏停防治组(药疗组)、对照组,每组15只.发现异搏停可减轻药疗组鼠应激时缺氧的程度;减少血小板聚集;缓解血栓素B_2(简称TXB_2)上升,并相对促进6-酮-PGF_(1α)(简称PGF_(1α))增加,达到调节TXB_2/PGF_(1α)比值(1.22),接近对照组水平(1.30),与冰浴组的TXB_2/PGF_(1α)比值上升至1.64相比,形成鲜明对照.电镜检查显示异搏停对冰浴应激引起的心肌强烈收缩,也有一定程度的保护作用.这些发现将有助于深入了解异搏停的多种抗心绞痛作用机制.
In this paper, 45 superficial anesthetized rats were divided into ice bath stimulation group (ice bath group), verapamil control group (treatment group), control group, each group of 15. Found that verapamil can reduce the treatment group rats (1α) (PGF_ (1α)) and increase the level of TXB_2 / PGF_ (1α) in response to hypoxia, reduce the degree of hypoxia, decrease the platelet aggregation, alleviate the increase of thromboxane B_2 (TXB_2) (1.22), which was close to the level of control group (1.30), which was in sharp contrast with the ratio of TXB_2 / PGF_ (1α) increased to 1.64 in the ice bath group.Electron microscopy showed that verapamil exerted a strong effect on myocardium induced by ice bath stress Contractions, but also a certain degree of protection These findings will help to understand the mechanism of multiple anti-angina pectoris.