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目的:观察转移因子治疗呼吸道反复感染患儿的近期效果。方法:对我院2008年11月至2011年11月治疗的166例呼吸道反复感染患儿的临床资料进行回顾性分析,将其随机分为A、B两组。A组82例,在对症治疗的基础上,给予每次皮下注射1U的转移因子,每周2次,达3周后减至每周一次,持续6周。B组84例在对症治疗的基础上,给予每次100mg的丙种球蛋白,隔15d进行1次肌内注射,完成3次。结果:A组的总有效率达到90.2%,B组的总有效率仅52.4%,两组相较,差异显著(P<0.01)。B组患儿的IgG指标同治疗前相较,明显升高(P<0.05),但IgA指标同治疗前相较,未见明显变化(P>0.05),A组患儿的IgG与IgA指标同治疗前相较,均明显上升(P<0.05)。结论:应用转移因子治疗呼吸道反复感染患儿,不仅近期疗效显著,且治疗总有效率较高,同时,患儿的IgG与IgA水平均明显上升,且不良反应较少,应予推广。
Objective: To observe the short-term effect of transfer factor in children with recurrent respiratory tract infection. Methods: The clinical data of 166 children with recurrent respiratory tract infection treated in our hospital from November 2008 to November 2011 were retrospectively analyzed. They were randomly divided into A and B groups. A group of 82 patients, on the basis of symptomatic treatment, given subcutaneous injection of 1U of transfer factor, twice a week, up to 3 weeks after the week down to 6 weeks. Group B, 84 patients on the basis of symptomatic treatment, given each 100mg of gamma globulin, once every 15d intramuscular injection, completed three times. Results: The total effective rate of group A reached 90.2%, while the total effective rate of group B was only 52.4%. There was significant difference between the two groups (P <0.01). The IgG index in group B was significantly higher than that before treatment (P <0.05), but there was no significant change in IgA before treatment (P> 0.05). The level of IgG and IgA in group A Compared with before treatment, both were significantly increased (P <0.05). Conclusion: The application of transfer factor in children with recurrent respiratory tract infection not only has a significant effect in the short term, but also has a high total effective rate of treatment. Meanwhile, IgG and IgA levels in children are significantly increased with fewer side effects and should be promoted.