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目的:通过对自然流产妇女蜕膜和血清中氧化应激指标--超氧化物歧化酶(SOD)、丙二醛(MDA)及维生素E(VitE)的测定,探讨氧化应激与自然流产的关系。方法:用化学比色法对30例自然流产妇女和20例正常早孕妇女蜕膜和血清中SOD、MDA及VitE进行测定。结果:与正常早孕妇女相比,自然流产妇女蜕膜和血清中MDA水平都升高(P<0.05),SOD、VitE水平却都下降(P<0.05,P<0.05)。结论:氧化应激与自然流产具有相关性。
OBJECTIVE: To investigate the relationship between oxidative stress and spontaneous abortion by measuring the levels of oxidative stress in decidua and serum of spontaneous abortion women: superoxide dismutase (SOD), malondialdehyde (MDA) and vitamin E relationship. Methods: The decidual and serum levels of SOD, MDA and VitE in 30 spontaneous abortion women and 20 normal pregnant women were determined by chemical colorimetry. Results: Compared with normal pregnant women, the levels of MDA in decidua and serum of spontaneous abortion women were increased (P <0.05), while the levels of SOD and VitE were decreased (P <0.05, P <0.05). Conclusion: Oxidative stress is associated with spontaneous abortion.