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心血管疾病是目前引起死亡的主要原因之一,血管再生和细胞治疗为治愈心血管疾病带来了希望。胚胎干细胞作为内皮细胞和组织工程材料的来源,为治疗心血管疾病提供了广泛的应用前景。本文详细讲解胚胎干细胞向内皮细胞定向诱导分化的方法、信号通路及相关的转录调控因了,为研究定向诱导胚胎干细胞向血管内皮细胞分化提供系统的方法和理论指导,同时为利用胚胎干细胞来源的内皮细胞治疗心血管疾病提供了理论基础。
Cardiovascular disease is one of the major causes of death at present, and revascularization and cell therapy promise to cure cardiovascular diseases. As a source of endothelial cells and tissue engineering materials, embryonic stem cells provide a wide range of applications for the treatment of cardiovascular diseases. In this article, we will explain in detail the methods, signaling pathways and related transcriptional regulation of ESCs induced by endothelial cells. In order to provide systematic methods and theoretical guidance for the directional differentiation of embryonic stem cells into vascular endothelial cells, Endothelial cells provide the theoretical basis for the treatment of cardiovascular diseases.