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目的 :考察头孢曲松钠与奥硝唑氯化钠注射液配伍的稳定性。方法 :采用紫外分光光度法确定两者的最大吸收波长 ,并测定两药配伍后不同时间的含量及吸收曲线的变化情况 ;用酸度计测定两药配伍后pH值并观察外观变化。 结果 :奥硝唑在 32 0nm ,头孢曲松钠在 2 4 1nm处有最大吸收。混合液在 8h内外观澄明 ,无沉淀产生 ;混合液吸收曲线未发生改变 ,也未见其他吸收峰产生 ;含量、pH值均无明显变化。 结论 :头孢曲松钠可以与奥哨唑氯化钠注射液配伍。
Objective: To investigate the compatibility of ceftriaxone sodium and ornidazole sodium chloride injection. Methods: The maximum absorption wavelength of the two drugs was determined by UV spectrophotometry. The contents of the two drugs at different times and the changes of absorption curve were determined. The pH value of the two drugs was determined by acidity meter and the changes of appearance were observed. Results: Ornidazole at 32 0nm, ceftriaxone maximum absorption at 214nm. The mixture was clear in appearance within 8h, no precipitate was produced. The absorption curve of the mixture did not change, and no other absorption peak was found. There was no obvious change in the content and pH value. Conclusion: Ceftriaxone sodium can be used in combination with metronidazole sodium chloride injection.