论文部分内容阅读
1病例报告患者男,23岁。因头晕、乏力2个月到某医院就诊,查血常规:WBC 10.8×109/L,RBC 5.21×1012/L,HB 159g/L,PLT1064×109/L。遂至我院诊治。查体:浅表淋巴结未触及,胸骨无压痛。彩超:肝脾大小正常。骨髓象:骨髓有核细胞增生活跃,巨核细胞系增生明显活跃,以颗粒巨、产板巨为主,巨核细胞112个/片,粒红两系正常。初诊为原发性血小板增多症(ET)。给予羟基脲片4g/d口服。7天后复查PLT 1228×109/L;送检骨髓MPL-Exon10突变(-),JAK2/V617F突变(-)。后至多
1 case report patient male, 23 years old. Due to dizziness, fatigue 2 months to a hospital for treatment, check the blood routine: WBC 10.8 × 109 / L, RBC 5.21 × 1012 / L, HB 159g / L, PLT1064 × 109 / L. Then to our hospital for treatment. Physical examination: superficial lymph nodes not touched, sternal no tenderness. Color Doppler ultrasound: normal liver and spleen size. Bone marrow: bone marrow nucleated cells hyperplasia, megakaryocyte hyperplasia was significantly active, with large particles, the main production plate giant, megakaryocytes 112 / piece, two normal red grading. Initial diagnosis of essential thrombocythemia (ET). Give hydroxyurea tablets 4g / d orally. PLT 1228 × 109 / L after 7 days; Marrow MPL-Exon10 mutation (-) and JAK2 / V617F mutation (-) were detected. After most