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对HBVDNA阳性病人血清进行检测，并观察e系统及ALT与之关系，结果表明：HBVDNA阳性病人ALT明显升高，与HBeAg阳性病人ALT成正相关，与抗HBe阳性病人ALT成负相关。同时乙肝患者HBVDNA与HBeAg同时阳性率远高于HBVDM与HBeAg阴性和HBVDNA阳性与抗HBe阳性的组合。结果提示：反映肝细胞损害程度的ALT的升高和HBeAg、HBVDNA同时阳性成正相关，临床上可考虑乙肝患者HBVDNA、HBeAg阳性和ALT异常作为HBV复制指标。
The serum of HBVDNA-positive patients was detected, and the relationship between e-system and ALT was observed. The results showed that ALT in HBVDNA-positive patients was significantly increased, positively correlated with ALT in HBeAg-positive patients and negatively correlated with ALT in anti-HBe-positive patients. At the same time, the positive rate of HBVDNA and HBeAg in hepatitis B patients is much higher than the combination of HBVDM and HBeAg negative and HBVDNA positive and anti-HBe positive. The results suggest that the elevation of ALT, which reflects the extent of hepatocellular damage, is positively correlated with the positive of HBeAg and HBVDNA. HBVDNA, HBeAg positive and abnormal ALT may be considered clinically as markers of HBV replication.