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目的 了解中药制剂“溃宁”口服液对幽门螺旋杆菌 (H pylori ,Hp)感染不同时间段的沙土鼠自由基的清除作用。方法 感染Hp2月模型 5 0只 ,随机分为 5组 (A、B、C、D、E组 )。感染Hp4月模型 2 0只 ,随机分为 2组 (F、G组 ) :A组为“西药三联组” :于第 1- 14天灌服克拉霉素、甲硝唑和雷尼替丁 ;第 15 - 2 8天 ,单用雷尼替丁。B组为“溃宁低剂量组” :灌服低剂量“溃宁”浸膏粉悬浊液 ,连用 2 8天。C组为“溃宁高剂量组” :灌服高剂量“溃宁”浸膏粉悬浊液 ,连用 2 8天。D组 (感染 2月综合用药组 ) :第 1- 14天同A组 ,第 15 - 2 8天 ,灌服高剂量“溃宁”浸膏粉悬浊液。E组 (感染 2月对照组 ) :灌服无菌蒸馏水 ,连用 2 8天。F组为“感染 4月综合用药组” :用药同D组。G组“感染 4月对照组” :处理同E组。结果 单独使用溃宁低剂量、溃宁高剂量、西药三联和西药三联 +溃宁高剂量组动物经治疗后 ,其过氧化脂质含量均低于同期感染的对照组 (P <0 0 5或P <0 0 1) ,但西药三联组 +溃宁高剂量组动物的过氧化脂质含量 ,则高于单独使用溃宁低剂量、溃宁高剂量和西药三联组动物 (P <0 0 5或P <0 0 1)。溃宁低剂量组动物的过氧化脂质含量低于西药三联组和西药三联 +溃宁高剂量组 (P<0 0 5或P <0 0 1) ,其治疗?
Objective To understand the scavenging effect of traditional Chinese medicine preparation “Funning” oral solution on free radicals of Helicobacter pylori (Hp) infection at different time intervals in gerbils. Methods A total of 50 Hp2 months infected models were randomly divided into 5 groups (A, B, C, D, E groups). Twenty-five Hp4 infection models were randomly divided into 2 groups (F, G group): A group was “Western medicine triple group”: clarithromycin, metronidazole and ranitidine were fed on days 1-14; Day 15 - 28, Ranitidine alone. Group B was “Fengning low-dose group”: It was fed with low-dose “Fengning” extract powder suspension for 28 days. Group C was “Feng Ning high-dose group”: high-dose “Fengning” extract powder suspension was fed for 28 days. Group D (Infective 2-month comprehensive drug group): On the 1st - 14th day of the same group A, on the 15th - 28th day, high-dose “Fengning” extract powder suspension was given. Group E (infection control group in February): fed sterile distilled water for 28 days. Group F was “infected with comprehensive drug group in April”: medication was the same as group D. Group G “infected with 4 months of control group”: treated with group E. Results After the treatment with animals treated with Kuning low dose, Kuning high dose, western medicine triple and western medicine triple combined with high dose of Kuning, their lipid peroxide content was lower than that of the control group (P < 0.05). P <0 0 1), but the peroxide lipid content of western medicine triple group + high-dose Wuling group animals was higher than that of Wuning low-dose, high-dose Kuning and western medicine triad groups alone (P <0 0 5 Or P <0 0 1). The lipid peroxide content in the low-dose group of Wuning group was lower than that of the Western medicine triple group and the western medicine triple-group + Kuning high-dose group (P<0 05 or P <0 01).