摩罗丹(浓缩丸)致肝损伤3例

来源 :药物不良反应杂志 | 被引量 : 0次 | 上传用户:fatcat120
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
3例患者(例1女,52岁,有甲型肝炎史;例2女,64岁;例3女,61岁)均因慢性胃炎给予摩罗丹(浓缩丸)16丸口服、3次/d。例1无合并用药,例2合并使用雷贝拉唑钠肠溶片,例3合并使用雷贝拉唑钠肠溶片及瑞巴派特片。例1、例2、例3分别在服用摩罗丹(浓缩丸)27、22、19 d后出现肝功能异常,丙氨酸转氨酶(ALT)均升高>5倍参考值上限,例2、例3伴胆红素升高。例1、例2、例3均立即停用摩罗丹(浓缩丸),分别在给予保肝治疗18、22、24 d后肝功能恢复正常。“,”Three patients (patient 1, a 52-year-old female, with a history of hepatitis; patient 2, a 64-year-old female; patient 3, a 61-year-old female) were all treated with n morodan concentrated pill (16 pills, thrice daily for all) for chronic gastritis. In patient 1, there were no combined drugs; in patient 2, sodium rabeprazole enteric-coated tablets were also used; in patient 3, sodium rabeprazole enteric-coated tablets and rebamipide tablets were combined. Patient 1, patient 2, and patient 3 developed abnormal liver function after 27, 22, and 19 days of n morodan concentrated pill administration, respectively. Their alanine aminotransferase (ALT) increased by more than 5 times the upper limit of the reference value, accompanied by elevated bilirubin in patient 2 and patient 3. All the 3 patients were stopped to use n morodan concentrated pill immediately. After 18, 22, and 24 days of liver-protective treatments, the liver function of patient 1, patient 2, and patient 3 returned to normal, respectively.n
其他文献
1例77岁男性患者行经直肠前列腺穿刺活检前为预防感染予左氧氟沙星0.5 g静脉滴注。静脉滴注结束后3 h,患者躯干、臀部、四肢出现红斑伴瘙痒,2 d后出现发热,皮疹加重和大面积水疱
1例31岁男性患者因肺部感染给予莫西沙星400 mg口服、1次/d。用药9 d后出现咯血、便血和全身散在瘀点、瘀斑,血小板计数(PLT)1×10n 9/L,诊断为血小板减少性紫癜。停用莫西沙
1例55岁男性肝复杂泡型包虫病患者有痛风病史4年余,入院等待远程会诊结果和准备接受择期右半肝切除术时,出现双足肿胀、皮温高等症状。实验室检查示尿酸530 μmol/L,风湿因子阴
1例63岁男性患者因膀胱癌肺转移接受纳武单抗(1 mg/kg)和伊匹木单抗(3 mg/kg)静脉滴注,1次/21 d。第2次用药后第3天,患者出现发作性胸闷,平卧数分钟后可自行缓解,实验室检查示超敏肌