Overexpression of MECP2 in the Suprachiasmatic Nucleus Alters Circadian Rhythm and Induces Abnormal

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Dear Editors,rnAutism spectrum disorder is a highly heritable neurodevel-opmental disorder and is often associated with sleep disorders and dysregulation of the circadian rhythm[1,2].Whether neural circuits governing the circadian rhythm are causally associated with social behaviors remains to be determined.In this work,we used mice with MECP2 duplication as a model of autism to inves-tigate whether regulation of the circadian rhythm is connected to social behaviors.
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