论文部分内容阅读
目的从血液流变学角度探讨活血化瘀方在肝病治疗中的应用。方法对160例患者资料进行回顾性分析。其中肝肾阴虚型78例,瘀血阻络型82例。研究组肝肾阴虚型39例,瘀血阻络型41例,对照组肝肾阴虚型39例,瘀血阻络型41例。对照组临床上服用拉夫米定药物治疗,研究组在对照组治疗的基础上联合活血化瘀方进行治疗。比较2组患者的红细胞聚集指数、血浆黏度、红细胞压积、全血高切黏度、全血低切黏度、红细胞膜SOD活力、红细胞膜MDA含量7个指标。结果肝肾阴虚型研究组的全血低切黏度、红细胞指数和红细胞膜MDA含量与对照组比较差异有统计学意义(P<0.05);瘀血阻络型研究组的全血低切黏度、血浆黏度、红细胞聚集指数和红细胞膜MDA含量与对照组比较差异有统计学意义(P<0.05)。结论活血化瘀药能够改善血液循环、血管通透性,保护肝细胞,促进炎症病灶的消退、软化和吸收增生性病灶,改善机体免疫功能。
Objective To study the application of Huoxue Huayu Recipe in the treatment of liver diseases from the perspective of hemorheology. Methods The data of 160 patients were retrospectively analyzed. 78 cases of liver and kidney yin deficiency, blood stasis blocking type of 82 cases. The study group, 39 cases of liver and kidney Yin, blood stasis blocking type in 41 cases, the control group of liver and kidney yin deficiency in 39 cases, blood stasis blocking type in 41 cases. The control group was treated with lamivudine clinically. The study group was treated on the basis of the control group with the combination of activating blood circulation and removing blood stasis. Erythrocyte aggregation index, plasma viscosity, hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, erythrocyte membrane SOD activity and erythrocyte membrane MDA content were compared between the two groups. Results The low blood viscosity, the erythrocyte index and the content of MDA in erythrocyte membrane in the study group were significantly different from those in the control group (P <0.05). The low blood viscosity , Plasma viscosity, erythrocyte aggregation index and erythrocyte membrane MDA content had statistical significance compared with the control group (P <0.05). Conclusion Activating blood circulation and removing blood stasis medicine can improve blood circulation, vascular permeability, protect liver cells, promote the regression of inflammatory lesions, soften and absorb hyperplastic lesions and improve immune function.