目的探讨尿激酶胸腔内注入治疗包裹性胸腔积液,注药后当次抽液的疗效。方法55例结核性网状粘连包裹性胸腔积液患者分为两组。治疗组28例在胸腔内注入尿激酶后10min内即抽液,对照组27例在胸腔内注入尿激酶2～3d后抽液。结果两组患者注药后首次抽液量、治疗后抽液总量无显著差异,但治疗组所需的注药次数、胸穿次数、胸水吸收时间显著少于对照组。治疗后B超测胸膜厚度两组无明显差异。结论胸腔内注入尿激酶后,短时间内(10min)即可达到很好的治疗胸膜粘连、包裹的作用,当次抽液较常规的注药2～3d后抽液有一定优势。 Objective To investigate the therapeutic effect of intrapleural injection of urokinase for encapsulated pleural effusion and fluid withdrawal after injection. Methods 55 patients with tuberculous reticular adhesive pleural effusion were divided into two groups. Twenty-eight patients in the treatment group were infused within 10 minutes after intrapleural injection of urokinase, and 27 patients in the control group were injected with urokinase for 2 to 3 days after intrathoracic injection. Results There was no significant difference between the two groups in the total amount of fluid withdrawn after treatment and the total amount of fluid withdrawn after treatment. However, the number of injection, the number of chest wear and the time of pleural effusion required by the treatment group were significantly less than those of the control group. B ultrasound treatment after treatment pleural thickness was no significant difference between the two groups. Conclusions After pleural injection of urokinase, the pleural adhesions and parcels can be well treated within a short period of time (10 min). When the time of pumping is 2 to 3 days after conventional injection, fluid extraction has some advantages.